After a long time, I can say I have a solution to prevent THIS

You MUST open a Powershell Window with elevated permissions and enter this

Add-AppxPackage -DisableDevelopmentMode -Path C:\Windows\SystemApps\Microsoft.Windows.SecHealthUI_cw5n1h2txyewy\AppxManifest.xml -Verbose -Register

After that, you are able to open Windows Defender normally.

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    • sylvain
    • August 2, 2019

    Thanks. It works but I have to do the same thing after reboot.

      • Domekologe
      • August 28, 2019

      Is there maybe a policy or software distribution management client installed?